Less Is More

Simpler & Better Medicine

Oral Risperidone, Haloperidol, or Placebo for Symptoms of in Palliative Care. — February 24, 2017

Oral Risperidone, Haloperidol, or Placebo for Symptoms of in Palliative Care.

Summary: For older patients in palliative care for a life-limiting illness, management of delirium with supportive care and individualized treatment of delirium precipitants may lead to improved delirium scores and fewer extra-pyramidal side effects compared to management with supportive care plus haloperidol or risperidone, and management with supportive care alone may lead to improved overall survival compared to management with supportive care plus haloperidol.

https://www.ncbi.nlm.nih.gov/m/pubmed/27918778/

Strength of Recommendation = B

Cancer risk in people exposed to computed tomography scans in childhood or adolescence. — July 12, 2016

Cancer risk in people exposed to computed tomography scans in childhood or adolescence.

Summary: Minimizing use of computed tomography (CT) scanning in children and adolescents appears to be associated with a slightly lower risk of developing a new cancer over the next (approximately) 9.5 years, and possibly with slightly lower lifetime risk of new cancer.

http://www.ncbi.nlm.nih.gov/m/pubmed/23694687/

Strength of Recommendation = B

Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial — July 5, 2016

Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial

Summary: For women living in areas with freely available access to appropriate adjuvant therapy for breast cancer, breast cancer screening by regular physical examination alone may be equivalent to breast cancer screening with regular mammography when evaluated in terms of 25 year risk of breast-cancer or all-cause mortality, but screening by physical examination alone may lead to a lower risk of over-diagnosis and a lower risk of over-treatment.

http://www.ncbi.nlm.nih.gov/m/pubmed/24519768/

Strength of Recommendation = B

Diagnostic Accuracy of Digital Screening Mammography With and Without Computer-Aided Detection. — March 1, 2016

Diagnostic Accuracy of Digital Screening Mammography With and Without Computer-Aided Detection.

Summary: For breast cancer screening, digital screening mammography performed withOUT computer-assisted detection (CAD) is less costly than digital mammography performed WITH CAD, without any loss of sensitivity or specificity. (In other words, use of CAD as an adjust to digital mammography screening adds cost without adding any improvement in screening performance.)

http://www.ncbi.nlm.nih.gov/m/pubmed/26414882/

Strength of Recommendation = B

Screening for Occult Cancer in Unprovoked Venous Thromboembolism. — November 9, 2015

Screening for Occult Cancer in Unprovoked Venous Thromboembolism.

Summary: For patients with unprovoked venous thromboembolism (VTE), limiting the screening for occult malignancy to a basic history and examination (basic lab testing, chest x-ray, and screening for breast, cervical, and prostate cancer) may work just as well as screening with history, examination and comprehensive computed tomography (CT) of the abdomen and pelvis.

http://www.ncbi.nlm.nih.gov/m/pubmed/26095467/

Strength of Recommendation = B

Chemotherapy Use, Performance Status, and Quality of Life at the End of Life. — August 20, 2015

Chemotherapy Use, Performance Status, and Quality of Life at the End of Life.

Summary: For patients with end-stage cancer (less than 6 months’ life expectancy) who have good performance status, avoiding late palliative chemotherapy may lead to a better quality of death than if palliative chemotherapy is used. (In other words, the quality of death for patients with end-stage cancer is not improved, and can be harmed, by chemotherapy use near death.)

http://www.ncbi.nlm.nih.gov/m/pubmed/26203912/

Strength of Recommendation = B

Performance of alternative strategies for primary cervical cancer screening in sub-Saharan Africa: systematic review and meta-analysis of diagnostic test accuracy studies — July 9, 2015

Performance of alternative strategies for primary cervical cancer screening in sub-Saharan Africa: systematic review and meta-analysis of diagnostic test accuracy studies

Summary: For primary cervical cancer screening in sub-Saharan Africa, use of visual inspection with acetic acid (VIA) or visual inspection with Lugol’s iodine (VILI) may be more specific than human papillomavirus (HPV) testing with hybrid capture or PCR, although all appear equally (highly) sensitive.

http://www.ncbi.nlm.nih.gov/m/pubmed/26142020/

Strength of Recommendation = B

Comparing hospice and nonhospice patient survival among patients who die within a three-year window. — July 6, 2015
%d bloggers like this: