Summary: For adults having 2-8 migraine attacks per month (with or without aura), use of melatonin 3 mg daily may provide more people with at least a 50% reduction in headache frequency than amitriptyline 25 mg daily, with a lower likelihood of side effects (such as sleepiness, dry mouth, weight gain or constipation).

https://www.ncbi.nlm.nih.gov/m/pubmed/27165014/

Strength of Recommendation = B

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