Summary: For adult patients hospitalized with community-acquired pneumonia (CAP), a practice of stopping antibiotics after 5 days’ treatment if the patient has been afebrile for 48 hours and has no more than one sign of clinical instability*, appears to be associated with a shorter overall duration of antibiotic treatment and a lower likelihood of hospital re-admission over the next 30 days (with no worse rates of clinical improvement or symptom improvement) compared to a practice of stopping antibiotics based on the clinical determination or impression of the treating physician.

* – Signs of clinical instability in CAP: Systolic blood pressure  < 90 mm Hg, heart rate >  100/min, respiratory rate > 24 /min,  oxygen saturation < 90%, or Pao2 < 60 mm Hg on room air.

Strength of Recommendation = B