Summary: For women at high-risk of pre-term birth, not using vaginal progesterone seems to be associated with the same rate of preterm birth as does the use of vaginal progesterone prophylaxis. (In otherwords, for women at high risk of pre-term birth, vaginal progesterone prophylaxis may not reduce that risk)

http://www.ncbi.nlm.nih.gov/m/pubmed/26921136/

Strength of Recommendation = A

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