Summary: For hospitalized patients with deep-vein thrombosis (DVT) of the proximal lower leg or the inferior vena cava, treatment with anticoagulation alone may be associated with lower rates of blood transfusion, pulmonary embolism, and intracranial hemorrhage compared to treatment with anticoagulation + catheter-directed thrombolysis (CDT); and the two procedures appear to be associated with the same risk of in-hospital mortality. (This study also found lower hospital costs and shorter lengths of stay associated with standard anticoagulation alone, compared to anticoagulation + CDT)

Strength of Recommendation = B