Summary: For adults who have in-hospital cardiac arrest with an initial shockable rhythm, adhering to current American Heart Association (AHA) guidelines to give epinephrine at least two minutes after the first defibrillation attempt is associated with higher odds of survival, return of spontaneous circulation (ROSC), and a good functional outcome. (In other words, epinephrine administered within two minutes after the first defibrillation (which is contrary to AHA guidelines) is associated with lower odds of survival, lower likelihood of return of spontaneous circulation (ROSC) and lower likelihood of a good functional outcome.)

http://www.ncbi.nlm.nih.gov/m/pubmed/27053638/

Strength of Recommendation = B

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