Summary: For patients with knee osteoarthritis (OA), placebo, “sham” or no-treatment works just as well as injectable hyaluronic acid (HA) for improving pain, stiffness, or function, and is less invasive. (In other words, HA injection for knee OA does not appear to provide any clinically significant benefit when compared to placebo)

http://www.ncbi.nlm.nih.gov/m/pubmed/26677239/

Strength of Recommendation = A

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