Summary: For patients with malignant pleural effusion needing pleurodesis, nonsteroidal anti-inflammatory drugs (NSAIDs) while a chest tube is in place may provide the same analgesic efficacy as opioids, without any increased risk of pleurodesis failure.

http://www.ncbi.nlm.nih.gov/m/pubmed/26720026/

Strength of Recommendation = B

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