Summary: For patients with acute COPD, and treated at presentation with IV methylprednisolone + a broad-spectrum antibiotic, treatment with a subsequent 5-day course of oral prednisone 40 mg daily works just as well for preventing subsequent COPD exacerbations as a 14 day course of prednisone 40 mg daily, but with a significantly lower overall glucocorticoid exposure.

Strength of Recommendation = B