Summary: For adolescents with major depression, patients who do not take paroxetine and imipramine may do just as well with their depression as those to take either medication, without the increased risks of suicidal ideation and behaviour associated with paroxetine, or the increased risk of cardiovascular problems associated with imipramine. (In other words, in this re-analysis study, adolescents with depression treated with paroxetine or imipramine did not have any significant improvement in depression measures than those treated with placebo, but they did have an increased risk of side effects)

Strength of Recommendation = B