Summary: For patients taking warfarin for secondary prevention of venous thromboembolism (VTE) (ie, those taking warfarin following an initial VTE), when warfarin is interrupted for an invasive diagnostic or surgical procedure, NOT using “bridging” anticoagulation may be associated with a lower risk of clinically relevant bleeding without any increased risk of VTE recurrence. (In other words, for patients on warfarin after a VTE, there is a lower risk of bleeding and no increased risk of recurrent VTE if “bridging” anticoagulation with heparins is not used.)

Strength of Recommendation = B