Summary: For patients with CT-confirmed uncomplicated appendicitis (ie, no suspicion of appendicolith, perforation, abscess, or tumor on CT imaging), treatment with intravenous antibiotics (3 days of IV ertapenem, then 7 days of oral levofloxacin + metronidazole) may both markedly decrease the need for surgical appendectomy, and lead to a lower post-operative complication rate in those patients who do require an appendectomy after initial antibiotic treatment.

Strength of Recommendation = B