Summary: For acute migraine headache, the combination of acetaminophen 500 mg + aspirin 500 mg +caffeine 130 mg (AAC) may be significantly more effective than sumatriptan 50 mg in the early treatment of migraine (specifically, AAC may provide significantly greater pain intensity reduction, may significantly reduce the need for rescue medication, and may lead to an increased likelihood of patients reporting little or no functional disability due to migraine).

Strength of Recommendation = B